Makoto Arita Selected Research

Eicosapentaenoic Acid

1/2022	Lipidomic analysis revealed n-3 polyunsaturated fatty acids suppressed choroidal thinning and myopia progression in mice.
11/2019	Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice.
1/2019	Preferential Incorporation of Administered Eicosapentaenoic Acid Into Thin-Cap Atherosclerotic Plaques.
12/2018	An omega-3 polyunsaturated fatty acid derivative, 18-HEPE, protects against CXCR4-associated melanoma metastasis.
1/2018	The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques.
1/2015	Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases.
1/2015	Aspirin and Eicosapentaenoic Acid May Arrest Progressive IgA Nephropathy: A Potential Alternative to Immunosuppression.
9/2014	Immunomodulation with eicosapentaenoic acid supports the treatment of autoimmune small-vessel vasculitis.
9/2014	Identification of novel omega-3 fatty acid-derived bioactive metabolites based on a targeted lipidomics approach.
3/2014	Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model.

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Makoto Arita Research Topics

Disease

48	Inflammation (Inflammations) 01/2022 - 04/2003
15	Peritonitis 12/2014 - 05/2003
8	Neoplasms (Cancer) 01/2019 - 05/2013
7	Contact Dermatitis (Eczema, Contact) 01/2022 - 06/2013
7	Asthma (Bronchial Asthma) 01/2021 - 02/2013
6	Hypersensitivity (Allergy) 01/2020 - 01/2015
4	Dermatitis 11/2022 - 01/2018
4	Neoplasm Metastasis (Metastasis) 01/2021 - 01/2014
4	Rhinosinusitis 01/2021 - 01/2019
4	Obesity 12/2020 - 12/2010
4	Colitis 08/2015 - 05/2005
3	Infections 04/2014 - 12/2005
2	Alzheimer Disease (Alzheimer's Disease) 06/2021 - 05/2013
2	Fibrosis (Cirrhosis) 05/2021 - 07/2014
2	Pneumonia (Pneumonitis) 01/2021 - 01/2010
2	Nasal Polyps (Nasal Polyp) 01/2020 - 01/2019
2	Atherosclerosis 01/2019 - 01/2011
2	Atherosclerotic Plaque (Atheroma) 01/2019 - 11/2014
2	Disease Progression 01/2019 - 05/2013
2	Hypertrophy 01/2017 - 09/2014
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2015 - 01/2010
2	Cardiovascular Diseases (Cardiovascular Disease) 11/2014 - 03/2005
1	Fatty Liver 07/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 07/2022
1	Carcinogenesis 01/2022
1	Bacterial Infections (Bacterial Infection) 01/2022
1	Myopia 01/2022
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2022
1	Chronic Renal Insufficiency 05/2021
1	Arteritis 01/2021
1	Mucocutaneous Lymph Node Syndrome (Kawasaki Disease) 01/2021
1	Gastritis 01/2021
1	Atopic Dermatitis (Atopic Eczema) 01/2021
1	Cysts 01/2021
1	Respiratory Tract Diseases (Respiratory Tract Disease) 01/2020
1	Hyperphagia (Overeating) 01/2020

Drug/Important Bio-Agent (IBA)

33	LipidsIBA 11/2022 - 05/2003
18	Eicosapentaenoic AcidIBA 01/2022 - 03/2005
17	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2022 - 09/2007
12	5S,12R,18R- trihydroxy- 6Z,8E,10E,14Z,16E- eicosapentaenoic acidIBA 10/2015 - 03/2005
9	Fatty Acids (Saturated Fatty Acids)IBA 11/2022 - 03/2005
9	ZymosanIBA 12/2014 - 08/2006
8	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2020 - 12/2010
7	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/2020 - 05/2003
6	Docosahexaenoic AcidsIBA 01/2021 - 09/2009
6	LipoxinsIBA 10/2012 - 05/2003
5	CytokinesIBA 01/2018 - 08/2009
4	Dinoprostone (PGE2)FDA Link 01/2022 - 04/2003
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2003
4	Arachidonic Acid (Vitamin F)IBA 01/2019 - 09/2007
3	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)IBA 01/2021 - 01/2013
3	Anti-Allergic Agents (Antiallergic Agents)IBA 11/2019 - 06/2015
3	17,18-epoxy-5,8,11,14-eicosatetraenoic acidIBA 01/2018 - 02/2014
3	EicosanoidsIBA 11/2017 - 05/2013
3	Dextran SulfateIBA 08/2015 - 01/2010
3	AcidsIBA 08/2015 - 01/2010
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2015 - 05/2005
3	lipoxin A4IBA 09/2014 - 02/2010
3	protectin D1IBA 03/2013 - 06/2007
2	AutacoidsIBA 07/2022 - 09/2005
2	HaptensIBA 01/2022 - 06/2013
2	Phospholipases (Phospholipase)IBA 01/2022 - 01/2017
2	Secretory Phospholipases A2IBA 01/2022 - 06/2013
2	ChemokinesIBA 01/2022 - 01/2016
2	Matrix Metalloproteinases (MMPs)IBA 06/2021 - 01/2014
2	Amyloid (Amyloid Fibrils)IBA 06/2021 - 05/2013
2	Prostaglandin D2IBA 05/2021 - 05/2013
2	EnzymesIBA 05/2021 - 06/2013
2	Interleukin-17 (Interleukin 17)IBA 01/2021 - 01/2018
2	CholesterolIBA 01/2021 - 11/2014
2	InterleukinsIBA 01/2021 - 03/2005
2	Phospholipids (Phosphatides)FDA LinkGeneric 01/2021 - 11/2017
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 04/2014
2	Biological ProductsIBA 01/2019 - 09/2016
2	LigandsIBA 01/2019 - 01/2010
2	Leukotriene B4IBA 01/2018 - 04/2003
2	Fish OilsIBA 01/2015 - 03/2005
2	SteroidsIBA 01/2015 - 09/2014
2	Interleukin-12 (IL 12)IBA 05/2005 - 03/2005
1	RNA (Ribonucleic Acid)IBA 11/2022
1	CarbohydratesIBA 07/2022
1	7,14- dihydroxydocosa- 4,8,10,12,16,19- hexaenoic acidIBA 07/2022
1	resolvin D1IBA 07/2022
1	Amino Acids FDA Link 07/2022
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2022
1	Peptides (Polypeptides)IBA 06/2021
1	Collagen Type I (Type I Collagen)IBA 05/2021
1	12-hydroxy-5,8,10,14,17-eicospentaenoic acidIBA 01/2021
1	CeramidesIBA 01/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	GlucocorticoidsIBA 01/2021
1	Retinoid X Receptors (Retinoid X Receptor)IBA 01/2021
1	Phosphatidylcholines (Phosphatidylcholine)IBA 01/2021
1	diazonaphthalenedisulfonic acid (NDS)IBA 01/2021
1	C-Type Lectins (C-Type Lectin)IBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 12/2020
1	Fluorescein (Funduscein)FDA LinkGeneric 01/2020
1	docosapentaenoic acidIBA 01/2020

Therapy/Procedure

6	Therapeutics 12/2018 - 09/2005
2	Intravenous Injections 12/2018 - 11/2014